Diabetic Complications - Can Benfotiamine Help Prevent Them?

Diabetic complications contribute too many life threatening diseases globally. The root cause of diabetic complications is elevated glucose levels which contribute to blood vessel damage. Diabetic retinopathy, nephropathy, or neuropathy are caused by damage to small blood vessel in the eyes, nerves and kidneys, etc. The bottom line of this damage is the lowering of the life expectancy of millions of diabetics worldwide.

What Can Be Done About It?

Few therapies are available today that treat diabetic complications. Most healthcare professionals recommend that their patients monitor their blood sugar by taking several blood readings a day to determine the amount of sugar in their blood. Blood sugar readings are generally higher from one to two hours after a meal.

It is suggested by these professionals that keeping blood sugar readings as close to normal as possible will reduce the onset of diabetic complications. Research has shown that there are four, chemical pathways that lead to diabetic complications. Instead of trying to explain these rather difficult chemical pathways, let the reader understand that diabetic complications are mainly caused by excess sugar in the cells, a condition known by the term advanced glycation endproducts (AGE) formation.

The research that was released in 2003 by a team of researchers from the Albert Einstein Collage of Medicine opened the possibilities that it may be possible to actually prevent and/or contain diabetic complications such as retinopathy, neuropathy and heart/circulatory conditions brought about by the presence of advanced glycation endproducts.

What Did This Research Suggest?

The Einstein researchers' work showed that a substance called, "benfotiamine", could reduce the effects of AGE by increasing the amount of an enzyme called transketolase. The research indicated that transketolase was increased by 300% which was enough to make a serious reduction of three of the four chemical pathways that open the door for diabetic complications in terms of vascular damage in diabetics. This vascular damage is directly responsible for the diabetic complications such as neuropathy, retinopathy and heart/circulatory conditions that lead to heart attack and stroke.

Can Benfotaimine Be Considered A Prudent Preventative?

Current research suggests that benfotiamine could possibly reduce the chances of diabetics developing the aforementioned complications. Many healthcare professionals readily recommend patients to add this nutritional supplement to their toolkit in the battle to prevent these insidious conditions that shorten the lives of thousands of diabetics annually.

Where Can I Find More Information About Benfotiamine?

More information about benfotiamine can be found by visiting the web site below and following the links. These links will give the reader a good base to make an informed decision about the use of benfotiamine in the battle against diabetic complications brought about by the presence of advanced glycation endproducts (AGE) which is excess sugar in the blood.

Research:

Hans-Peter Hammes, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nature Medicine 9, 294 - 299 (01 Mar 2003).

Michael Brownlee. Biochemistry and molecular cell biology of diabetic complications Nature 414, 813 - 820 (13 Dec 2001).

Roya Babaei-Jadidi, Nikolaos Karachalias, Naila Ahmed, Sinan Battah, Paul J. Thornalley. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine ? Complications. Diabetes. (August 2003).

Zach Malott is CEO of Brentwood Health International, a nutritional supplement company involved in distribution and supplying wholesale, retail and end users.

Mr. Malott is available to discuss the research as it applies to benfotiamine in the treatment and prevention of diabetic complications such as neuropathy and retinopathy.

He can be reached at:

Phone: 505.354.0526

Website: http://www.emuhealthproducts.com

In The News:

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A pair of specialists work on the floor of the New York Stock Exchange, Monday, Dec. 1, 2008. (AP Photo/Richard Drew)AP - Confirmation that the nation is in a recession and signs pointing to a prolonged downturn sent Wall Street plunging once again Monday, hurtling the Dow Jones industrials down nearly 700 points and more than half of last week's big gains. All the major indicators more than 7 percent, and the Standard & Poor's 500 index dropped nearly 9 percent.



President-elect Barack Obama, left, stands with Secretary of State-designate Sen. Hillary Rodham Clinton, D-N.Y., center, and National Security Adviser-designate Ret. Marine Gen. James Jones, right, at a news conference in Chicago, Dec. 1, 2008. (AP Photo/Pablo Martinez Monsivais)AP - President-elect Barack Obama picked a national security team headed by former campaign rival Hillary Rodham Clinton and Bush administration holdover Robert Gates on Monday, and said he wants to consult with military commanders before settling on a firm timetable to withdraw U.S. combat troops from Iraq.



A sale sign is posted at jewlery store in Daly City, Calif., Monday, Nov. 24, 2008. The economy took a tumble in the summer that was worse than first thought as American consumers throttled back their spending by the most in 28 years, further proof the country is almost certainly in the throes of a painful recession. (AP Photo/Paul Sakuma)AP - The U.S. economy has been in a recession since December 2007, the National Bureau of Economic Research said Monday. The NBER — a private, nonprofit research organization — said its group of academic economists who determine business cycles met and decided that the U.S. recession began last December.



Tape covers bullet holes in the windows of the newly-reopened Refresh Cafe in the landmark Chhatrapati Shivaji Terminus train station, in Mumbai, India, Monday Dec. 1, 2008.  This scarred and traumatized city struggled back to its feet Monday, reopening schools and businesses, as residents tried to come to terms with the string of terror attacks that brought bloodshed to the heart of Mumbai. The owner of the cafe said he had little choice but to reopen the fast food restaurant in the station, even though its glass wall is scarred with bullet holes, half his staff refused to come back and his brother is on a ventilator in the intensive care unit after being shot in the abdomen by the attackers. (AP Photo/Lefteris Pitarakis)AP - India demanded Monday that Pakistan take "strong action" against those behind the deadly Mumbai attacks, and Washington pressured Islamabad to cooperate with the investigation.



Alaska Gov. Sarah Palin, center, waves to a crowd during a campaign stop for U.S. Sen. Saxby Chambliss, R-Ga, Monday, Dec. 1, 2008 in Savannah, Ga. Chambliss and Democratic challenger Jim Martin are   in a Tuesday runoff that will shape Democrats' hold on power in Washington. (AP Photo/Stephen Morton)AP - Alaska Gov. Sarah Palin urged Georgia voters to back Sen. Saxby Chambliss in Tuesday's runoff in an election eve appeal that underscored her popularity within the Republican Party and the GOP's efforts to stave off erosion of its shrinking Senate numbers.



U.S. Secretary of State Condoleezza Rice smiles during a press conference with  Britain's Foreign Secretary David Miliband after their meeting  in London, Monday, Dec. 1, 2008. President-elect  Barack Obama  announced Monday that Hillary Rodham Clinton  will be the next Secretary of State. (AP Photo/Akira Suemori)AP - Happily contemplating another woman as the top U.S. diplomat, Secretary of State Condoleezza Rice said Monday she will offer advice, privately, and then get out of the way.



AP - Almost one in five young American adults has a personality disorder that interferes with everyday life, and even more abuse alcohol or drugs, researchers reported Monday in the most extensive study of its kind.

In this Oct. 29, 2007 file photo, socialite Ivana Trump and Rossano Rubicondi attend the 2007 G&P Foundation 10th Annual Angel Ball in New York. (AP Photo/Evan Agostini, file)AP - Ivana Trump has issued a statement confirming reports of marital discord with Italian entrepreneur Rossano Rubicondi. Trump, who married Rubicondi in April, says she filed a legal separation agreement three months ago. Trump says she kept quiet about it because she didn't want to ruin Rubicondi's chances as a contestant on the Italian edition of the reality TV show "Survivor."



AP - A man who rammed his truck into a woman's vehicle on a highway early Friday told authorities he crashed into her while going more than 100 mph because God told him "she needed to be taken off the road."

New York Giants' Plaxico Burress, right, arrives at Manhattan Supreme Court for arraignment with an unidentified man on Monday, Dec. 1, 2008 in New York. Burress accidentally shot himself at a Manhattan nightclub Friday evening and was treated at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. He was released Saturday.  (AP Photo/David Karp)AP - Plaxico Burress was led out of a police precinct in handcuffs Monday after surrendering on a weapons possession charge, and authorities said that teammate Antonio Pierce is being investigated over his role in an accidental shooting at a Manhattan nightclub.



President-elect Barack Obama announces that Sen. Hillary Clinton will be his choice for Secretary of State during a news conference in Chicago December 1, 2008. (John Gress/Reuters)Reuters - U.S. President-elect Barack Obama named former rival Hillary Clinton as secretary of state on Monday and said Robert Gates would remain defense secretary in a national security team charged with recasting America's leadership role in the world.



A trader on the floor of the New York Stock Exchange, November 13, 2008. (Brendan McDermid/Reuters)Reuters - Stocks tumbled on Monday as news pointing to the deepening economic slump around the world erased much of last week's sharp gains, with financial services companies and retailers among Wall Street's biggest casualties.



Members of ZAKA, Israel's non-governmental rescue-and-recovery organization which specializes in collecting human remains to ensure a proper Jewish burial, speak with policemen after performing religious rituals in front of Nariman House in Mumbai's Colaba area, December 1, 2008. (Jayanta Shaw/Reuters)Reuters - India demanded Pakistan take decisive action over deadly attacks in Mumbai it said were carried out by militants from its nuclear-armed rival, while the West urged cooperation to ease tension.



President Bush and first lady Laura Bush walk to make a statement on the attacks in Mumbai on the South Lawn of the White House, November 29, 2008. (Yuri Gripas/Reuters)Reuters - President George W. Bush said the biggest regret of his presidency was flawed intelligence that Iraq had weapons of mass destruction and told ABC "World News" in an interview airing on Monday that he was unprepared for war when he took office.



A woman watches as people shop in the Time's Square Toys 'R' Us store on 'Black Friday' in New York, November 28, 2008. (Brendan McDermid/Reuters)Reuters - The U.S. economy has slumped into a recession, the nation's business cycle arbiter declared on Monday, while European leaders clashed over how much public money to spend tackling a deepening downturn.



Speaker of the House Rep. Nancy Pelosi speaks during a news conference in the U.S. Capitol in Washington November 21, 2008. (Molly Riley/Reuters)Reuters - U.S. House of Representatives Speaker Nancy Pelosi met leading governors on Monday to discuss the size and shape of an economic stimulus package that one Democratic aide said was likely to cost around $500 billion.



An anti-government demonstrator chases after a suspected pro-government supporter in Bangkok's Suvarnabhumi Airport on December 1, 2008. (Kerek Wongsa =/Reuters)Reuters - Thai protesters prepared to end their three-month occupation of the Prime Minister's office on Monday to consolidate their grip on the main airport ahead of a court verdict that could dissolve the elected government.



Birmingham Mayor Larry P. Langford in an undated photo. (Handout/Reuters)Reuters - Federal authorities arrested the mayor of Birmingham, Alabama, on Monday in a corruption probe surrounding a massive sewer bond debt that has forced Jefferson County to the brink of bankruptcy.



Arizona Governor Janet Napolitano, President-elect Barack Obama's choice for homeland security chief, speaks at a press conference at the Hilton Hotel in Chicago, Illinois. Obama on Monday nominated Hillary Clinton to be his AFP - Barack Obama on Monday nominated Hillary Clinton to be his "tough," "smart" secretary of state as his former foe vowed to give her all to steer America through a storm of international crises.



Map locating the attacks in Mumbai. India has formally accused AFP - India on Monday formally accused "elements" in Pakistan of being behind the devastating Islamic militant attacks in Mumbai and demanded that Islamabad take "strong action".




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